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fmoc protected phe analogs  (Chem Impex International)


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    Chem Impex International fmoc protected phe analogs
    Fmoc Protected Phe Analogs, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/phe+analogs/Fmoc-p-phenyl-L-phenylalanine/pm39969055-415-12-18
    Average 95 stars, based on 4 article reviews
    fmoc protected phe analogs - by Bioz Stars, 2026-09
    95/100 stars

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    other:

    Article Title: Stabilization of a protein by a single halogen‐based aromatic amplifier
    Article Snippet: The protocol for solid‐phase synthesis is as described (Merrifield et al. ). (Fmoc)‐protected Phe analogs were purchased from Chem‐Impex International (Wood Dale, IL).

    Article Title: Tuning phenylalanine fluorination to assess aromatic contributions to protein function and stability in cells.
    Article Snippet: The other Phe analogs were acquired commercially as follows: 2F Phe -Astatech, cat # 73308;4F Phe- Chem-impex cat # 02572; 2,4F Phe1ClickChemistry, cat #5C96757; 2,5F Phe- Astatech, cat # 60350; 2,6FPhe HCl salt- Chem-impex, cat #24171; 3,5F Phe Chem-impex, cat # 04123; 2,3,6F-Phe- Astatech, A50355; 3,4,5F Phe- Chem-impex, cat # 07394; 2,3,4,5F Phe- Enamine, cat # en300-27751009; 2,3,4,5,6F PheChem-impex, cat # 07183.



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    p52 suppress food intake independently of GPR10 and GPR74 expression in mice . A. Wild-type mice were treated with vehicle, liraglutide (dose) or the indicated concentration of p52 at the onset of the dark cycle and food intake was monitored over the subsequent 4 h (n = 8 per group). B Wild-type (WT) (n = 7), 10KO (n = 9), 74KO (n = 5), and 10/74KO (n = 5) mice were treated with vehicle or p52 (5 mg/kg) at the onset of the dark cycle and food intake was monitored over the subsequent 4 h. All graphs: Shown is mean ± SEM. One-way ANOVA, Dunnett's multiple comparisons test and unpaired t-test were used; p values are shown for significant comparisons. ∗: p < 0.05, ∗∗: p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗: p < 0.0001.

    Journal: Molecular Metabolism

    Article Title: Roles for Prlhr /GPR10 and Npffr2 /GPR74 in feeding responses to PrRP

    doi: 10.1016/j.molmet.2024.102093

    Figure Lengend Snippet: p52 suppress food intake independently of GPR10 and GPR74 expression in mice . A. Wild-type mice were treated with vehicle, liraglutide (dose) or the indicated concentration of p52 at the onset of the dark cycle and food intake was monitored over the subsequent 4 h (n = 8 per group). B Wild-type (WT) (n = 7), 10KO (n = 9), 74KO (n = 5), and 10/74KO (n = 5) mice were treated with vehicle or p52 (5 mg/kg) at the onset of the dark cycle and food intake was monitored over the subsequent 4 h. All graphs: Shown is mean ± SEM. One-way ANOVA, Dunnett's multiple comparisons test and unpaired t-test were used; p values are shown for significant comparisons. ∗: p < 0.05, ∗∗: p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗: p < 0.0001.

    Article Snippet: The long-acting PrRP analog p52 (Palm-SRTHR HS-Nle-EI RTPDI NPAWY ASRGI RPVGR Phe(pNO2)-amide) was synthesized on a Prelude (Gyros Protein Technologies) by automated synthesis using the Fmoc/ t Bu protocol, purified by reversed-phase HPLC and characterized by single quadrupolar LC/MS using a Waters Mass Lynx 3100 platform.

    Techniques: Expressing, Concentration Assay

    p52, but not NTS PrlhOX or the activation of NTS Prlh neurons, suppresses locomotor activity in mice . A. Locomotor activity in wild-type mice treated with vehicle and p52 (n = 12, 5 mg/kg IP), respectively. B. Locomotor activity in Prlh Cre (n = 6; Ctrl-WT) and NTS PrlhOX (n = 7, PrlhOX-WT) mice. C. Locomotor activity in control mice (Ctrl; n = 9) and NTS Prlh−Dq mice (Dq; n = 3) treated with either saline or CNO (1 mg/kg IP) twice daily. All graphs: Shown is mean beam breaks per hour ± SEM for the light cycle, the dark cycle, and averaged over the entire 24-hour day. Multiple paired t-tests, Holm-Šídák method and Šídák-Bonferroni method were used; p values are shown for significant comparisons. ∗: p < 0.05, ∗∗: p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗: p < 0.0001.

    Journal: Molecular Metabolism

    Article Title: Roles for Prlhr /GPR10 and Npffr2 /GPR74 in feeding responses to PrRP

    doi: 10.1016/j.molmet.2024.102093

    Figure Lengend Snippet: p52, but not NTS PrlhOX or the activation of NTS Prlh neurons, suppresses locomotor activity in mice . A. Locomotor activity in wild-type mice treated with vehicle and p52 (n = 12, 5 mg/kg IP), respectively. B. Locomotor activity in Prlh Cre (n = 6; Ctrl-WT) and NTS PrlhOX (n = 7, PrlhOX-WT) mice. C. Locomotor activity in control mice (Ctrl; n = 9) and NTS Prlh−Dq mice (Dq; n = 3) treated with either saline or CNO (1 mg/kg IP) twice daily. All graphs: Shown is mean beam breaks per hour ± SEM for the light cycle, the dark cycle, and averaged over the entire 24-hour day. Multiple paired t-tests, Holm-Šídák method and Šídák-Bonferroni method were used; p values are shown for significant comparisons. ∗: p < 0.05, ∗∗: p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗: p < 0.0001.

    Article Snippet: The long-acting PrRP analog p52 (Palm-SRTHR HS-Nle-EI RTPDI NPAWY ASRGI RPVGR Phe(pNO2)-amide) was synthesized on a Prelude (Gyros Protein Technologies) by automated synthesis using the Fmoc/ t Bu protocol, purified by reversed-phase HPLC and characterized by single quadrupolar LC/MS using a Waters Mass Lynx 3100 platform.

    Techniques: Activation Assay, Activity Assay, Control, Saline